Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs GERANYL DIPHOSPHATE 10 mg
Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. This item is non returnable
Enzo Life Sciences MMP-Inhibitor profiling kit, colorimetric (1x96wells)
A QUANTIZYME Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a chromogenic substrate1,2 detected at 412nm. Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Applications: Colorimetric detection, HTS Activity assay.
Apexbio Technology LLC Oxaliplatin, 61825-94-3, MFCD00866327, 50 mg
MF: C8H14N2O4Pt, MW: 397.29, Solubility: 37.25mg/mL in DMSO, 3.94mg/mL in H2O with gentle warming. Oxaliplatin inhibits DNA synthesis, primarily by conforming DNA adducts. Oxaliplatin, a platinum compound, has a broad spectrum of anti-tumor activity and has demonstrated a lack of cross-resistance with other platinum compounds. Oxaliplatin induces primary and secondary DNA lesions that lead to cell apoptosis.
Echelon Biosciences Research Labs BODIPY FL-PI(3,5)P2 50 ug
BODIPY FL PI(3,5)P2 (BODIPY FL Phosphatidylinositol 3,5-bisphosphate) is a water soluble analog of PI(3,5)P2 labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). This item is non returnable
Echelon Biosciences Research Labs PI(5)P PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Echelon Biosciences Research Labs TNF converting Enzyme Substrate - 5 mg, CAS#: 192723-42-5
TNF converting Enzyme Substrate - 5mg , Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 Category/Application: Enzyme Substrates This item is non returnable
Abcam Glucose 6 Phosphate Dehydrogenase Activity Assay Kit (Fluorometric)
Glucose 6 Phosphate Dehydrogenase Activity Assay Kit (Fluorometric)
The product is subject to the following: Abcam Restricted Use Statement
Echelon Biosciences Research Labs GERANYLGERANIOL 10 mg
(E,E,E)-Geranylgeraniol is an intermediate in the biosynthetic pathway of vitamins E & K and is linked to proteins via post-translational modification. This item is non returnable
Medchemexpress LLC MC-Val-Cit-PAB-vinblastine | 2055896-92-7 | 99.5% | 1366.62 | C74H97N10O15 | 10 MG
MC-Val-Cit-PAB-vinblastine is a drug-linker conjugate for antibody-drug conjugate (ADC) research that links the microtubule inhibitor vinblastine to a cleavable val-cit-PAB-type linker. It is supplied as a white to light brown solid (CAS 2055896-92-7), with molecular formula C74H97N10O15 and molecular weight 1366.62 g/mol. Intended for research and analytical applications; not for human therapeutic use.
- Drug-linker conjugate designed for ADC research
- Vinblastine payload with microtubule inhibitory activity
- Cleavable linker for lysosomal release
- High purity suitable for analytical applications
- Solid form, white to light brown appearance
- Storage recommendations: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month)
- Available as a 10 mg pack
Apexbio Technology LLC 3-Methyladenine, 5142-23-4, MFCD00010531, 50 mg
MF: C6H7N5, MW: 149.15, Solubility: 7.45mg/mL in DMSO, 5mg/mL in H2O. 3-Methyladenine is an inhibitor of class III phosphoinositide 3-kinase (PI3K).
Echelon Biosciences Research Labs APP Gamma Secretase Inhibitor - 5 mg, CAS#: 208255-80-5
APP Gamma Secretase Inhibitor - 5mg , N-[N-(3,5-Difluorophenacetyl)-Ala]-S-phenylglycine t-butyl ester Category/Application: Enzyme Substrates This item is non returnable
Cell Signaling Technology SignalSlide Phospho-ErbB Family IHC Controls 1 Pack
SignalSlide Phospho-ErbB Family IHC Controls 1 Pack